Our research utilizes cutting edge technologies encompassing molecular genomics, phenomics, physiology, pathology, statistics and breeding to research strategies that contribute to the development of superior crop varieties. Our focus involves genomic prediction and selection, association mapping and characterization of allelic diversity
Deniz Akdemir and Julio Isidro y Sánchez
TrainSel is an R package developed for optimization task in the training set (TRS) while performing statistical analysis or machine learning approaches. It solves combinatorial problems using metaheuristics like simulated annealing (SA) and Genetic algorithms (GA) to find the best subset within the whole TRS.
Deniz Akdemir, Julio Isidro Sánchez, Hanna Haikka, Itaraju Baracuhy Brum
Implements the mate selection approach in: Akdemir and Sanchez. ”Efficient Breeding by Genomic Mating.” Frontiers in Genetics (2016).
Deniz Akdemir, Mohamed Somo, Julio Isidro Sanchez
Combine partial covariance matrices using a Wishart-EM algorithm. It can be used to combine partially overlapping covariance matrices from independent trials, partially overlapping multi-view relationship data from genomic experiments, partially overlapping Gaussian graphs described by their covariance structures.
Deniz Akdemir
Combining Predictive Analytics and Experimental Design to Optimize Results. To be utilized to select a test data calibrated training population in high dimensional prediction problems and assumes that the explanatory variables are observed for all of the individuals.
Julio Isidro Sánchez, Simon Rio and Deniz Akdemir
10.1201/9781003214991-2
Javier Fernández-González, Deniz Akdemir and Isidro y Sánchez, J
Submitted
Fahimeh Shahinnia et. al, Isidro y Sánchez, J
https://doi.org/10.1007/s00122-022-04202-z
Rio S, Akdemir D, Carvalho T, Isidro y Sánchez, J
https://doi.org/10.1007/s00122-021-03972-2
Isidro y Sánchez, J and Deniz Akdemir
https://doi.org/10.3389/fpls.2021.715910
Simon Rio, Luis Gallego-Sánchez, Gracia Montilla-Bascón,
Francisco J. Canales, Isidro y Sánchez, J and Elena Prats
https://doi.org/10.1007/s00122-021-03916-w
Akdemir D, Rio S and Isidro y Sánchez, J.
https://doi.org/10.3389/fgene.2021.655287
Isidro y Sánchez, J., D’Arcy Cusack, K., Verheecke‐Vaessen, C., Kahla, A., Bekele, W., Doohan, F., Magan, N. and Medina, A.
https://doi.org/10.1002/tpg2.20023
Deniz Akdemir, Ron Knox and Julio Isidro-Sánchez
https://doi.org/10.3389/fpls.2020.00947
Isidro y Sánchez, J., Elena Prats, Catherine Howarth, Tim Langdon, Gracia Montilla-Bascón
https://link.springer.com/chapter/10.1007/978-3-319-93381-8_4
Deniz Akdemir and Isidro-Sánchez Julio
https://doi.org/10.1038/s41598-018-38081-6
Gul, A., Diepenbrock, et.al and Isidro y Sánchez, J.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119521358
Deniz Akdemir, William Beavis, Roberto Fritsche-Neto, Asheesh K.Singh Isidro y Sánchez, J.
https://doi.org/10.1038/s41437-018-0147-1
Kumar S, Knox R, Asheesh K.Singh, Depauw Ron, Campbell Heather, Isidro y Sánchez, J., et al.
https://doi.org/10.1371/journal.pone.0192261
Isidro y Sánchez, J., Ben Perry, Asheesh K. Singh, Hong Wang, Ronald M. DePauw et al.
https://doi.org/10.2134/agronj2016.09.05278
Akdemir D, Jannink JL, Isidro y Sánchez, J.
https://doi.org/10.1186/s12711-017-0348-8
Akdemir D, Isidro y Sánchez, J.
https://doi.org/10.3389/fgene.2016.00210
Isidro-Sánchez J, Akdemir D, Burke J.
The World Wheat Book: A History of Wheat Breeding, Vol. 3, Chapter 32, eds A. William, B. Alain, and V. G. Maarten (Paris: Lavoisier), 1001–1023.
Isidro-Sánchez J, Akdemir D, Montilla-Bascón, G.
https://link.springer.com/protocol/10.1007%2F978-1-4939-6682-0_14
Montilla-Bascón, Gracia, Corey D. Broeckling, O. Hoekenga, E. Prats, M. Sorrells and Isidro-Sánchez J.
https://link.springer.com/protocol/10.1007%2F978-1-4939-6682-0_8
Isidro y Sánchez, J., Jannink JL, Akdemir D, Poland J, Heslot N, Sorrells ME.
https://doi.org/10.1007/s00122-014-2418-4
Akdemir, D., Isidro y Sánchez, J., Jannink JL.
https://doi.org/10.1186/s12711-015-0116-6
Isidro y Sánchez, J., Knox R, Singh A.K, Clarke F.R, Krishna P, DePauw R.M, Clarke, J.M, Somers D
https://doi.org/10.1007/s00425-012-1603-4
Isidro y Sánchez, J., Knox R, Singh A.K, Clarke F.R, DePauw R.M, Clarke, J.M, Somers
D
https://doi.org/10.1007/s00425-012-1728-5
Isidro y Sánchez, J., Alvaro F, Royo C, Villegas D, Miralles D, Garcıa del Moral,L.
https://doi.org/10.1093/aob/mcr063
Alvaro F, Isidro-Sánchez J, Villegas D, Garcia del Moral, L, Royo C
https://doi.org/10.1016/j.fcr.2007.11.003
Alvaro F, Isidro y Sánchez, J., Villegas D, Garcia del Moral L, Royo C.
https://doi.org/10.2134/agronj2007.0075
Isidro y Sánchez, J., Alvaro F, Royo C, Villegas D, Miralles D, Garcıa del Moral,L.
https://doi.org/10.1007/s10681-006-9327-9
There have been many scientific reports evaluating models and accuracy of GAB in plant breeding programs. However, the information on how, when, and why to apply GAB tools in real plant breeding programs is scarce. The main reason for this lack of information is that most plant breeding programs are private, and also GAB applications are in relatively new tools. Here, we aim to apply knowledge driven genomic prediction tools from a empirical public breeding program that will help to deliver general guideline applications of this technology.
This study aims to characterize Zymoseptoria tritici infections and perform genome predictions and genome-wide association analysis on wheat and also on the pathogen. In this project we seek to perform genome analysis to gain a better understanding of the pathosystem and to predict the evolution and incidence of pathogens to anticipate future pathogen attacks to crops by studying host-pathogen interactions.
Wheat (the second most important crop worldwide) yields are not currently increasing at comparable rates to those achieved in previous decades. Exploitation of the full range of available genetic resources (pre-breeding) could help develop new varies that will be needed in the future. The emergent technologies based on Artificial Intelligence and Machine learning are interesting tools to handle the huge volumes of genotypic and phenotypic data that are generated from agronomic and biological experiments. The aim of this PhD project is to develop statistical and programming tools to exploit and decode the hidden patterns underlying data and apply this knowledge on real breeding problems in both academical and industrial fields.
This project aims to provide a benchmark guideline on genomic assisted breeding for Syngenta sunflowerbreeding program by building tools and models that augment current practices capitalizing on advances in genomics, phenomics, imaging technologies, and machine learning.
Feeding an increasing global population in the face of global climate change is a challenge for the agricultural sector and governments alike. Developing new species with more desirable characteristics is critical, but so is its regulation. Creating the concept of high-performance low-risk (HPLR) varieties within the realm of value for cultivation and use (VCU) testing would help focus on this pressing need while introducing European harmonisation of VCU testing. InnoVar is developing tools and models to enhance current VCU and 'Distinctness, Uniformity and Stability' (DUS) testing practices by exploiting high-tech genomics, imaging and machine learning technologies. Next-generation variety testing will help countries and breeders focus on the challenge of feeding the next generations.
WheatSustain will establish a close collaboration among world leading experts on genomic prediction modelling in plants and animals, bioinformatics, wheat genomics and leaders in the field of plant pathology and host-pathogen relationships for stripe rust and FHB resistance in wheat. An interdisciplinary research team is established involving cutting-edge research groups from Norway, Ireland, Germany, Austria, Mexico, USA and Canada. Plant breeders from public and private breeding programs will take active part in the research by providing germplasm with phenotypic and genotypic data, take part in disease evaluations and test out the developed breeding methodologies in their breeding programs.
This study aims to perform an association mapping analysis of hexaploid oat (Avena sativa L.) cultivars for resistance to mycotoxins produced by Fusarium langsethiae, by detecting genetic variants involved in the resistance using Genome-Wide Association (GWA) analysis. In addition, a screening of a wide range of heritage Irish oat genotypes for distinct gene expression profiles relevant to differential mycotoxin contamination profiles will be performed. Finding regions of the genome associated with resistance to F. langsethiae will highlight chromosome locations of the oat genome that could be used as hotspots for further studies.
Granted-96K. PI. Julio Isidro-Sánchez.
295K. PI. Julio Isidro-Sánchez.
Scientific advisor of WPs.
A proposed project as part of the National Research Council Wheat Flagship Program and the Canadian Wheat Improvement Consortium. 14 million. Postdoctoral Project.
AGRNEX2008N0475. Postdoctoral Project.
ICFPN502A3PR03 (ICA3NCTN2002N10085), 963K. PhD. Project.
AGL2002-04285-C03-02. 65K. Member of the Research team of this project.
AGL2006-09226-C02-02- 02/AGR. 45K. Member of the Research team of this project.
AGL2005-07257- C04-04. 28K. Member of the Research team of this project.